Hot Towel is an ASP.NET 4 project for a single page application built with Knockout, Durandal, and Breeze.
Out of the box, it provides a modular structure for your code, view navigation, data binding, rich data management and simple but elegant styling. Hot Towel provides everything you need to build a SPA, so you can focus on your app, not the plumbing.
Hot Towel was written by John Papa who describes it vividly on his blog.